The majority of the game's set list are works by Aerosmith, but there are also works by artists that have acted as inspirations or touring partners for the band such as Run-D.M.C., The Kinks, and Joan Jett.
It is the first title in the series to focus primarily on the works of one specific band, Aerosmith. It is the second expansion title to the Guitar Hero series of video games, and was released in June 2008 for the Xbox 360, PlayStation 2, PlayStation 3, and Wii game consoles. Guitar Hero: Aerosmith is a music video game developed by Neversoft and published by Activision.